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p-IFN-α/βRα1 Antibody (Tyr 466)-R: sc-13114-R

 |  Datasheet

(Based on data analysis)
  • p-IFN-α/βRα1 (Tyr 466)-R Antibody is a rabbit polyclonal IgG provided at 200 µg/ml
  • recommended for detection of Tyr 466 phosphorylated IFN-αR1 of human origin by WB, IP, IF and ELISA
  • blocking peptide, sc-13114 P
 

See additional Interferon Receptor Antibodies including Interferon Receptor, IFN-αB, IFN-alpha / beta R alpha, IFN-alpha / beta R beta, IFN-alpha R1, IFN-gamma R, IFN-gamma R alpha and IFN-gamma R beta.

Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-IFN-α/βRα1 (Tyr 466)-R P sc-13114 P
(peptide)
 100 µg/0.5 ml $61
p-IFN-α/βRα1 (Tyr 466)-R Antibody sc-13114-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IFN-α/βRα siRNA (h) sc-35637 10 µM $258
IFN-α/βRα (h)-PR sc-35637-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IFN-α/βRα shRNA Plasmid (h) sc-35637-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IFN-α/βRα shRNA (h) Lentiviral Particles sc-35637-V 200 µl $625

The type I interferons (IFNs), å and ∫ , are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The å and ∫ IFNs appear to compete with one another for binding to a common cell surface receptor (1–4). Components of the receptor for IFN-å and ∫ include a 331 amino acid transmembrane glycoprotein, designated IFN-å/∫R (5) and a 557 amino acid component designated IFN-åR (6,7). The latter protein, IFN-åR, is weakly responsive to type I interferons in contrast to IFN-å/∫R, which binds to and responds effectively to IFN-∫ and to several of the IFN-å subtypes (5). Treatment of cells with IFN-a causes the IFN-åR1 subunit of the IFN-å receptor to become phosphorylated at Tyr-466 (8). The region surrounding phosphorylated Tyr-466 binds the SH2 domain of Stat2, facilitating its phosphorylation and, thus enhancing IFN- a signal transduction (8).