epitope corresponding to amino acids 1-70 mapping at the N-terminus of VEGF-B of human origin
recommended for detection of VEGF-B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine and porcine
VEGF-B Background Information The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1. The genes that encode human VEGF-B and VEGF-C have been localized to chromosomes 11q13 and 4q34, respectively.
VEGF-B (H-70) Product Citations
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VEGF-B (H-70)
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VEGF-B (H-70): sc-13083. Western blot analysis of human recombinant VEGF-B fusion protein.
