MAGE-H1 Background Information The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-H1 (Melanoma-associated antigen H1), also known as Restin or APR1 (Apoptosis-related protein 1), is a 219 amino acid protein that contains a type II MAGE homology domain (MHD). Enhanced ligand stimulation promotes MAGE-H1 interaction with the type II death domain of NGFR p75. It is suggested that MAGE-H1 accelerates differentiation in response to nerve growth factor in cells.
MAGE-H1 (H-21)
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MAGE-H1 (H-21): sc-130813. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.
MAGE-H1 (H-21): sc-130813. Western blot analysis of MAGE-H1 expression in Jurkat whole cell lysate.
