LysRS Background Information The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. LysRS (lysyl-tRNA synthetase), also known as KARS, KRS or KARS2, exists as both mitochondrial and cytoplasmic isoforms (625 and 576 amino acids, respectively) that belong to the tRNA synthetase family and are thought to play a role in autoimmune diseases, such as polymyositis or dermatomyositis. The gene encoding LysRS maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
LysRS (F-25)
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LysRS (F-25): sc-130806. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue showing cytoplasmic localization.
LysRS (F-25): sc-130806. Western blot analysis of LysRS expression in Jurkat whole cell lysate.
LysRS (F-25): sc-130806. Western blot analysis of LysRS expression in HeLa whole cell lysate.
