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- rabbit polyclonal IgG, 100µg/ml
- recommended for detection of IDE of human origin by WB, IP, IF, IHC(P) and ELISA
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
IDE |
3416 |
10q23.33 |
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P14735
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146680 |
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IDE Background Information
Insulin degrading enzyme (IDE), initiates the cleavage of insulin, resulting in insulin response and resistance. However, IDE also degrades a variety of bioactive peptides, including amyloid-∫ peptides, implicating IDE in certain age-related changes seen in Alzheimer’s disease. Studies show that when the expression of the IDE gene (chromosome 10q23.3) is altered, changes occur not only in glucose homeostasis, but also in the levels of brain Abeta40 and Abeta42 peptides. An IDE inhibitor, bacitracin, inhibits degradation of both insulin and amylin, indicating that both are degraded through a common proteolytic pathway. Variations in the rate of proteolysis suggest that the function of IDE exhibits conformational dependence, which may lead to possible therapeutic interventions for diabetes, AD, and other diseases associated with IDE substrate proteolysis. |
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IDE (A-23)
Click on image to enlarge
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IDE (A-23): sc-130784. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.
IDE (A-23): sc-130784. Western blot analysis of IDE expression in A-375 whole cell lysate.
IDE (A-23): sc-130784. Western blot analysis of IDE expression in MES-SA/Dx5 (A), Hep G2 (B) and A-375 (C) whole cell lysates.
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