eIF4B Background Information The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. These interactions are facilitated, in part, by the eukaryotic initiation factor 4 family (eIF4) of proteins that are involved in the early initiation of protein synthesis. eIF4B (eukaryotic translation initiation factor 4B) is a 611 amino acid protein that contains one RNA recognition motif and belongs to the eIF4 protein family. Required for proper mRNA/ribosome binding, eIF4B associates with other eIF4 proteins, such as eIF4A, and promotes the ATP-dependent unwinding activity of select eukaryotic initiation factors. The gene encoding eIF4B maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
eIF4B (T-24)
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eIF4B (T-24): sc-130749. Western blot analysis of eIF4B expression in K-562 whole cell lysate.
eIF4B (T-24): sc-130749. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.
eIF4B (T-24): sc-130749. Western blot analysis of eIF4B expression in non-transfected (A) and human eIF4B transfected (B) 293 whole cell lysates.
