ACTR-IIA Background Information Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion.
ACTR-IIA (A-24)
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ACTR-IIA (A-24): sc-130679. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic and membrane localization.
ACTR-IIA (A-24): sc-130679. Western blot analysis of ACTR-IIA expression in non-transfected (A) and human ACTR-IIA transfected (B) 293 whole cell lysates.
