Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Tumor Suppressors/Apoptosis » Bim Antibodies » Bim Antibody (Ham 151-149): sc-130511

Bim Antibody (Ham 151-149): sc-130511

 |  Datasheet

(Based on data analysis)
  • Bim Antibody (Ham 151-149) is a Armenian hamster monoclonal IgG1 provided at 200 µg/ml
  • raised against a Bim and Bcl-XL complex of mouse origin
  • recommended for detection of Bim of mouse origin by IP and FCM
  • fluorescein (sc-130511 FITC) and phycoerythrin (sc-130511 PE) conjugates for FCM, 100 tests
 

See additional Bim Antibodies including Bim, BimEL and BimEL/L.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
IP   FCM   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Bim Antibody (Ham 151-149) sc-130511 200 µg/ml $279
Bim Antibody (Ham 151-149) FITC sc-130511 FITC 100 tests in 2 ml $292
Bim Antibody (Ham 151-149) PE sc-130511 PE 100 tests in 2 ml $303
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bim siRNA (m) sc-29803 10 µM $258
Bim (m)-PR sc-29803-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bim shRNA Plasmid (m) sc-29803-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bim shRNA (m) Lentiviral Particles sc-29803-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Bcl2l11 12125 2 F1 O54918
 N/A
 

Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins, and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS and BimL, implying a unique role for BimEL in cell survival signaling.