epitope corresponding to amino acids 81-380 of FEN-1 of human origin
recommended for detection of FEN-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
FEN-1 Background Information DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. FEN-1 (for flap endonuclease) is an endonuclease that specifically cleaves the 5’ flap structure of DNA in the process of DNA repair. FEN-1 is highly homologous to yeast RAD2. The C-terminal region of FEN-1 may bind to PCNA, thus allowing FEN-1 to function as an exonuclease in DNA replication.
FEN-1 (H-300) Product Citations
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FEN-1 (H-300)
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FEN-1 (H-300): sc-13051. Western blot analysis of FEN-1 expression in HeLa (A) and Jurkat (B) nuclear extracts.
FEN-1 (H-300): sc-13051. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
FEN-1 (H-300): sc-13051. Western blot analysis of FEN-1 expression in non-transfected 293T: sc-117752 (A), mouse FEN-1 transfected 293T: sc-120234 (B) and HeLa (C) whole cell lysates.
