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IL-31R Antibody (N5D): sc-130484

 |  Datasheet

(Based on data analysis)

  • IL-31R Antibody (N5D) is a mouse monoclonal IgG2a provided at 100 µg/ml
  • recommended for detection of IL-31R of human origin by IF, IHC(P) and ELISA
 

See additional IL-31R Antibodies.

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IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
IL-31R Antibody (N5D) sc-130484 100 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IL-31R siRNA (h) sc-60839 10 µM $258
IL-31R (h)-PR sc-60839-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IL-31R shRNA Plasmid (h) sc-60839-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IL-31R shRNA (h) Lentiviral Particles sc-60839-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IL31RA 133396 5q11.2 Q8NI17
609510
 


IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

IL-31R Antibody (N5D) Data
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IL-31R (N5D): sc-130484. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human spleen tissue showing cytoplasmic and membrane localization.
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