DCTD Background Information DCTD (Deoxycytidylate deaminase), also known as dCMP deaminase, is a 178 amino acid allosteric enzyme that exists as a homohexamer and belongs to the cytidine and deoxycytidylate deaminase protein family. Using zinc as a cofactor, DCTD catalyzes the deamination of dCMP to dUMP, thereby producing the nucleotide substrate (dUMP) that is used by thymidylate synthase (TS). TS uses 5,10-methyl-enetetrahydrofolate (methylene-THF) and dUMP in the synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor for DNA biosynthesis. Due to its role in the synthesis of dUMP, DCTC plays an important role in the creation of DNA. The activity of DCTD is regulated by the presence of dCTP and dTTP, two end products in the DCTD metabolic pathway. Multiple isoforms of DCTD are expressed due to alternative splicing events.
DCTD (22D12)
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DCTD (22D12): sc-130367. Western blot analysis of DCTD expression in human DCTD transfected (A) and non-transfected (B) 293T whole cell lysates.
DCTD (22D12): sc-130367. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane localization.
