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home » Transcription Regulators » Sp1, Sp2, Sp3 and Sp4 Antibody / Sp1, Sp2, Sp3 and Sp4 Antibodies » Sp4 (H-270): sc-13019

Sp4 (H-270) Antibody: sc-13019

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 171-440 of Sp4 of human origin
  • recommended for detection of Sp4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-13019 X, 200 µg/0.1 ml
 
Additional Sp1, Sp2, Sp3 and Sp4 Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SP4 6671 7p15.3 NM_003112 Q02446
 600540
Mouse Sp4 20688 12 F2 Q62445
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Sp4 (H-270) sc-13019 200 µg/ml $279
Sp4 (H-270) X sc-13019 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Sp4 siRNA (h) sc-36545 10 µM $258
Sp4 siRNA (m) sc-36546 10 µM $258
Sp4 (h)-PR sc-36545-PR 10 µM $23
Sp4 (m)-PR sc-36546-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Sp4 shRNA Plasmid (h) sc-36545-SH 20 µg $520
Sp4 shRNA Plasmid (m) sc-36546-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Sp4 shRNA (h) Lentiviral Particles sc-36545-V 200 µl $625
Sp4 shRNA (m) Lentiviral Particles sc-36546-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NIH/3T3 nuclear extract sc-2138 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

Sp4 Background Information
The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share similar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the ∫4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription.

Sp4 (H-270) Product Citations
See how others have used Sp4 (H-270): sc-13019 antibody and or Sp4 (H-270) antibody conjugates.


4 total citations
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Sp4 (H-270)
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sc-13019
Sp4 (H-270): sc-13019. ChIP analysis of Sp4 recruitment to genomic amplicons. Four (1-4) different human genomic Sp-1 and two control amplicons (5,6) were analyzed by quantitative PCR (primer sequences available in on-line supplemental data). Data generated in collaboration with Drs. N. Trinklein and R. Myers, Stanford University (ENCODE project).
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