MAGE-A11 (N-16) Antibody: sc-130162

MAGE-A11 Background Information
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-A11 (melanoma antigen family A, 11), also known as MAGE11, MAGE-11, MAGEA-11 or CT1.11 (cancer/testis antigen 1.11), is a 429 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one MAGE domain. Expressed in a variety of tumors, including melanoma, breast cancer and lung cancer, MAGE-A11 functions as an androgen receptor (AR) co-regulator that modulates the interdomain of AR, thereby increasing its activity. Through its regulation of AR, MAGE-A11 is thought to play an important role in embryonic development and tumor progression/transformation. Two isoforms of MAGE-A11 exist due to alternative splicing events.