MAGE-A10 Background Information The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-A10 (melanoma antigen family A, 10), also known as MAGE10 or CT1.10 (Cancer/testis antigen 1.10), is a 369 amino acid protein that contains one MAGE domain and is thought to play a role in embryonic development and tumor progression. Like other members of the MAGE family, MAGE-A10 is expressed in head and neck squamous cell carcinoma, melanoma, breast cancer and lung cancer, suggesting that MAGE-A10 plays an important role in carcinogenesis.
MAGE-A10 (C-23)
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MAGE-A10 (C-23): sc-130161. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.
MAGE-A10 (C-23): sc-130161. Western blot analysis of MAGE-A10 expression in HL60 whole cell lysate.
