epitope corresponding to amino acids 15-300 of cyclin F of human origin
recommended for detection of cyclin F of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
cyclin F Background Information Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2-cyclin B complex controls G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin F is the largest of the cyclins described to date. It contains an extensive PEST-rich C-terminus and a cyclin box region that is most related to cyclins A and B. Cyclin F is ubiquitously expressed in human cells but fluctuates dramatically through the cell cycle, peaking in G2 like cyclin A and decreasing prior to decline of cyclin B. Cyclin F exhibits regulated subcellular localization, being localized in the nucleus in most cells, with a significant percentage of cells showing only perinuclear staining.
cyclin F (H-300)
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cyclin F (H-300): sc-13009. Western blot analysis of cyclin F expression in Ramos nuclear extract.
