Evi-1 Background Information The Evi-1 proto-oncogene contains two zinc finger domains, the second of which is essential for transactivation of the c-Fos promoter and for AP-1 activation. The first zinc finger domain binds to Smad3, suppressing its activity and inhibiting TGF∫ signaling. The t(3;21) (q26;q22) chromosomal translocation produces a chimeric transcription factor, AML-1/Evi-1, that appears to suppress the transactivation of AML-1, which is a stimulator of myeloid cell differentiation. Inappropriate Evi-1 gene expression in hemato-poietic cells has been shown to be associated with acute myelogenous leukemia (AML) and myelodysplastic syndromes.
Evi-1 (2331C1a1)
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Evi-1 (2331C1a1): sc-130025. Western blot analysis of human recombinant Evi-1 fusion protein.
Evi-1 (2331C1a1): sc-130025. Western blot analysis of Evi-1 expression in non-transfected: sc-117752 (A) and human Evi-1 transfected: sc-177200 (B) 293T whole cell lysates.
Evi-1 (2331C1a1): sc-130025. Western blot analysis of Evi-1 expression in non-transfected: sc-117752 (A) and human Evi-1 transfected: sc-177201 (B) 293T whole cell lysates.
Evi-1 (2331C1a1): sc-130025. Western blot analysis of Evi-1 expression in non-transfected: sc-117752 (A) and human Evi-1 transfected: sc-177200 (B) 293T whole cell lysates.
Evi-1 (2331C1a1): sc-130025. Western blot analysis of Evi-1 expression in HeLa whole cell lysate.
