epitope mapping near the C-terminus of TAL1 of human origin
recommended for detection of TAL1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-12983 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-12983 X, 200 µg/0.1 ml
TAL1 Background Information Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
TAL1 (G-19)
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TAL1 (G-19): sc-12983. Western blot analysis of TAL1 expression in HEL 92.1.7 whole cell lysate.
