Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Transcription Regulators » TAL Antibodies » TAL1 Antibody (E-14): sc-12982

TAL1 Antibody (E-14): sc-12982

 |  Datasheet

(Based on data analysis)

  • TAL1 Antibody (E-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the N-terminus of TAL1 of human origin
  • recommended for detection of TAL1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
  • blocking peptide, sc-12982 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-12982 X, 200 µg/0.1 ml
  • See 6 citations for TAL1 Antibody (E-14)
 

See additional TAL Antibodies including TAL, TAL1 and TAL2.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
TAL1 Antibody (E-14) sc-12982 200 µg/ml $279
TAL1 (E-14) P sc-12982 P
(peptide)
 100 µg/0.5 ml $61
TAL1 Antibody (E-14) X sc-12982 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
TAL1 siRNA (h) sc-36608 10 µM $258
TAL1 siRNA (m) sc-36609 10 µM $258
TAL1 (h)-PR sc-36608-PR 10 µM, 20 µl $23
TAL1 (m)-PR sc-36609-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
TAL1 shRNA Plasmid (h) sc-36608-SH 20 µg $520
TAL1 shRNA Plasmid (m) sc-36609-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
TAL1 shRNA (h) Lentiviral Particles sc-36608-V 200 µl $625
TAL1 shRNA (m) Lentiviral Particles sc-36609-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NIH/3T3 nuclear extract sc-2138 250 µg/0.05 ml $143
CCRF-CEM nuclear extract sc-2146 250 µg/0.05 ml $143
Jurkat nuclear extract sc-2132 250 µg/0.05 ml $143
K-562 nuclear extract sc-2130 250 µg/0.05 ml $143
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TAL1 6886 1p33 NM_003189 P17542
 187040
Mouse Tal1 21349 4 D1 P22091
 N/A
 

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

TAL1 Antibody (E-14) Product Citations
See how others have used TAL1 Antibody (E-14) and or TAL1 Antibody (E-14) conjugates.


6 total citations
Loading citations.
 
TAL1 Antibody (E-14) Data
Click on image to enlarge
sc-12982
TAL1 (E-14): sc-12982. Western blot analysis of TAL1 expression in NIH/3T3 nuclear extract.
sc-12982
TAL1 (E-14): sc-12982. Western blot analysis of TAL1 expression in non-transfected: sc-117752 (A) and human TAL1 transfected: sc-172270 (B) 293T whole cell lysates.
Download
Datasheets
Get Adobe Acrobat Reader