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p-gp130 Antibody (Ser 782): sc-12978

 |  Datasheet

(Based on data analysis)

  • p-gp130 Antibody (Ser 782) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-12978-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Ser 782 of gp130 of human origin
  • recommended for detection of Ser 782 phosphorylated gp130 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-12978 P
  • See 2 citations for p-gp130 Antibody (Ser 782)
 

See additional gp130 Antibodies.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-gp130 Antibody (Ser 782) sc-12978 200 µg/ml $279
p-gp130 (Ser 782) P sc-12978 P
(peptide)
 100 µg/0.5 ml $61
p-gp130 Antibody (Ser 782)-R sc-12978-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
gp130 siRNA (h) sc-29333 10 µM $258
gp130 siRNA (m) sc-35502 10 µM $258
gp130 (h)-PR sc-29333-PR 10 µM, 20 µl $23
gp130 (m)-PR sc-35502-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
gp130 shRNA Plasmid (h) sc-29333-SH 20 µg $520
gp130 shRNA Plasmid (m) sc-35502-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
gp130 shRNA (h) Lentiviral Particles sc-29333-V 200 µl $625
gp130 shRNA (m) Lentiviral Particles sc-35502-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IL6ST 3572 5q11.2 NM_002184, NM_175767 P40189
 600694
Mouse Il6st 16195 13 D2.2 Q00560
 N/A
 

IL-6 activates intracellular signaling by binding to IL-6R (the IL-6 receptor), which subsequently associates with a second protein, known as gp130. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. The major phosphorylation site of human gp130 is located immediately N-terminal to the di-leucine motif of gp130, which regulates the internalization of the receptor. Phospho-rylation of this site, Ser 782, regulates cell surface expression of the receptor polypeptide.

p-gp130 Antibody (Ser 782) Product Citations
See how others have used p-gp130 Antibody (Ser 782) and or p-gp130 Antibody (Ser 782) conjugates.


1 total citations
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p-gp130 Antibody (Ser 782) Data
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sc-12978
gp130 (Ser 782): sc-12978-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic, membrane and nuclear staining of myocytes.
sc-12978
Western blot analysis of gp130 phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) c4 whole cell lysates. Antibodies tested include p-gp130 (Ser 782)-R: sc-12978-R (A,B) and gp130 (M-20): sc-656 (C,D).
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