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home » Synthesis and Degradation » NOS Antibody / NOS Antibodies » p-NOS3 (Ser 1177): sc-12972

p-NOS3 (Ser 1177) Antibody: sc-12972

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-12972-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Ser 1177 of NOS3 of human origin
  • recommended for detection of Ser 1177 phosphorylated NOS3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-12972 P
 
Additional NOS Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NOS3 4846 7q36.1 NM_000603 P29474
 601367
Mouse Nos3 18127 5 A3 P70313
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-NOS3 (Ser 1177) sc-12972 200 µg/ml $279
p-NOS3 (Ser 1177) P sc-12972 P
(peptide)
 100 µg/0.5 ml $61
p-NOS3 (Ser 1177)-R sc-12972-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NOS3 siRNA (h) sc-36093 10 µM $258
NOS3 siRNA (m) sc-36094 10 µM $258
NOS3 (h)-PR sc-36093-PR 10 µM $23
NOS3 (m)-PR sc-36094-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NOS3 shRNA Plasmid (h) sc-36093-SH 20 µg $520
NOS3 shRNA Plasmid (m) sc-36094-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NOS3 shRNA (h) Lentiviral Particles sc-36093-V 200 µl $625
NOS3 shRNA (m) Lentiviral Particles sc-36094-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NOS3 (m): 293T Lysate sc-122097 100µg/200µl $205
ECV304 Cell Lysate sc-2269 500 µg/200 µl $104

NOS3 Background Information
Nitric oxide (NO), produced by the endothelial NO synthase (NOS3), is a fundamental determinant of cardiovascular homeostasis that maintains system blood pressure, vascular remodeling and angiogenesis. NOS3 is stimulated, in a phosphatidylinositol 3-kinase (PI 3-kinase)-dependent fashion, by treatment of endothelial cells with insulin-like growth factor-1 and vascular endothelial growth factor (VEGF). The serine/ threonine protein kinase Akt/PKB is an important downstream target of PI 3-kinase, regulating VEGF-stimulated endothelial cell survival. NOS3 activation via phosphorylation of serine 1177 by Akt/PKB is necessary and sufficient for VEGF-mediated endothelial cell migration. Therefore, Akt/PKB can directly phosphorylate NOS3 on serine 1177, activating the enzyme and leading to NO production.

p-NOS3 (Ser 1177) Product Citations
See how others have used p-NOS3 (Ser 1177): sc-12972 antibody and or p-NOS3 (Ser 1177) antibody conjugates.


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p-NOS3 (Ser 1177)
Click on image to enlarge
sc-12972
p-NOS3 (Ser 1177)-R: sc-12972-R. Western blot analysis of NOS3 phosphorylation in non-transfected: sc-117752 (A) and mouse NOS3 transfected: sc-122097 (B) 293T whole cell lysates.
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