p-TAL1 (Ser 122) Antibody: sc-12962

TAL1 Background Information
Activation of tal-1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL-1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL-1 and the catalytic subunit of casein kinase II alpha, a serine/threonine protein kinase known to modulate the activity of other bHLH transcription factors. Phosphorylation of serine 122 is induced by epidermal growth factor with a rapid time course that parallels activation of the ERK/MAP2 protein kinases. Phospho-rylation of serine 122 is a substrate for the mitogen-activated protein kinase ERK1 (extracellularsignal-regulated protein kinase).