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p-NIK (Thr 559) Antibody: sc-12957 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope corresponding to phosphorylated Thr 559 of NIK of human origin
- recommended for detection of Thr 559 phosphorylated NIK of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-12957 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MAP3K14 |
9020 |
17q21.31 |
NM_003954 |
Q99558
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604655 |
| Mouse |
Map3k14 |
53859 |
11 E1 |
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Q9WUL6
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N/A |
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NIK Background Information
The NFkB transcription factor can be activated by several cytokines including TNF and IL-1. The TNF receptor activates NFkB through the TRAF2 adaptor protein (1,2), whereas the IL-1 receptor activates NFkB in a pathway involving TRAF6 (3). Both TRAF2 and TRAF6 interact with a serine/threonine kinase designated NFkB inducing kinase (NIK), which appears to participate in the NFkB signaling cascades triggered by both TNF and IL-1 (4,5). Upon phosphorylation of Thr-559 within its kinase domain, NIK is activated (6–8). Subsequently, NIK phosphorylates IkB kinase a (IKKa), which, in turn, phosphorylates IkB resulting in IkB degradation and NFkB activation (6–8).
| p-NIK (Thr 559) Product Citations |
See how others have used p-NIK (Thr 559): sc-12957 antibody and or p-NIK (Thr 559) antibody conjugates.
8 total citations Loading citations.
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p-NIK (Thr 559)
Click on image to enlarge
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p-NIK (Thr 559)-R: sc-12957-R. Western blot analysis of NIK phosphorylation in untreated (A) and lambda protein phosphatase treated (B) A549 whole cell lysates.
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