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home » Structural Proteins » Caldesmon Antibody / Caldesmon Antibodies » p-Caldesmon (Ser 789): sc-12931

p-Caldesmon (Ser 789) Antibody: sc-12931

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-12931-R
  • recommended for detection of Ser 789 phosphorylated H-Caldesmon and correspondingly phosphorylated L-Caldesmon I and II of mouse, rat and human origin by WB, IP, IF and ELISA
  • blocking peptide, sc-12931 P; also reactive with additional species, including equine, canine, bovine and porcine
 
Additional Caldesmon Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CALD1 800 7q33 NM_004342, NM_033138, NM_033139, NM_033140, NM_033157 Q05682
 114213
Mouse Cald1 109624 6 B1 NP_663550
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-Caldesmon (Ser 789) sc-12931 200 µg/ml $279
p-Caldesmon (Ser 789) P sc-12931 P
(peptide)
 100 µg/0.5 ml $61
p-Caldesmon (Ser 789)-R sc-12931-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
Caldesmon (m): 293T Lysate sc-118955 100µg/200µl $205

Caldesmon Background Information
S3-v-Erb B is a retroviral oncogene that encodes a ligand-independent, transforming mutant of the epidermal growth factor receptor. Expression of S3-v-Erb B in primary fibroblasts results in the tyrosine phosphorylation of Caldesmon. Caldesmon is an Actin- and calmodulin-binding protein; the phosphorylated form of Caldesmon is associated with a signaling Shc/GRB2 complex. Tyrosine 27, which is located within the Myosin binding domain of Caldesmon, is one of the major sites of phosphorylation. Tyrosine phospho-rylation of Caldesmon enhances its binding to the Shc/GRB2 complex. Acetylcholine increases phosphorylation of Caldesmon at Serine 789, and extracellular signal-regulated kinases (ERKs) phosphorylate Caldesmon at Serine 789 during smooth muscle stimulation, indicating that Caldesmon is a putative downstream target of MAP kinase pathways.

p-Caldesmon (Ser 789) Product Citations
See how others have used p-Caldesmon (Ser 789): sc-12931 antibody and or p-Caldesmon (Ser 789) antibody conjugates.


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p-Caldesmon (Ser 789)
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sc-12931
p-Caldesmon (Ser 789)-R: sc-12931-R. Western blot detection of L-Caldesmon phosphorylation in NIH/3T3 cells treated with anisomycin (A,B). The antibody was preincubated with cognate phosphorylated (A) or non-phosphorylated (B) peptide.
sc-12931
p-Caldesmon (Ser 789): sc-12931. Immunofluorescence staining of methanol-fixed BC3H1 cells showing cytoskeletal localization.
sc-12931
p-Caldesmon (Ser 789)-R: sc-12931-R. Western blot analysis of Caldesmon phosphorylation in non-transfected 293T: sc-117752 (A), truncated mouse Caldesmon transfected 293T: sc-118955 (B) and NIH/3T3 (C) whole cell lysates.
sc-12931
p-Caldesmon (Ser 789)-R: sc-12931-R. Western blot analysis of Caldesmon phosphorylation in non-transfected: sc-117752 (A), untreated mouse Caldesmon transfected: sc-118955 (B) and lambda protein phosphatase treated mouse Caldesmon transfected: sc-118955 (C) 293T whole cell lysates.
sc-12931
Western blot analysis of p-Caldesmon phosphorylation in non-transfected: sc-117752 (A,D), untreated mouse p-Caldesmon transfected: sc-118955 (B,E) and lambda protein phosphatase treated mouse Caldesmon transfected: sc-118955 (C,F) 293T whole cell lysates. Antibodies tested include p-Caldesmon (Ser 789)-R: sc-12931-R (A,B,C) and Caldesmon (H-300): sc-15374 (D,E,F).
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