p-Caldesmon (Tyr 27)-R Antibody: sc-12930-R

caldesmon Background Information
S3-v-Erb B is a retroviral oncogene that encodes a ligand-independent, transforming mutant of the epidermal growth factor receptor. Expression of S3-v-Erb B in primary fibroblasts results in the tyrosine phosphorylation of Caldesmon. Caldesmon is an Actin- and calmodulin-binding protein; the phosphorylated form of Caldesmon is associated with a signaling Shc/GRB2 complex. Tyrosine 27, which is located within the Myosin binding domain of Caldesmon, is one of the major sites of phosphorylation. Tyrosine phospho-rylation of Caldesmon enhances its binding to the Shc/GRB2 complex. Acetylcholine increases phosphorylation of Caldesmon at Serine 789, and extracellular signal-regulated kinases (ERKs) phosphorylate Caldesmon at Serine 789 during smooth muscle stimulation, indicating that Caldesmon is a putative downstream target of MAP kinase pathways.