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p-Cdc6 Antibody (Ser 106): sc-12922

 |  Datasheet

(Based on data analysis)

  • p-Cdc6 Antibody (Ser 106) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-12922-R
  • recommended for detection of Ser 106 phosphorylated Cdc6 of human origin by WB, IP and IF
  • blocking peptide, sc-12922 P; also reactive with additional species, including equine, canine and porcine
  • See 1 citations for p-Cdc6 Antibody (Ser 106)
 

See additional Cdc Antibodies including Cdc, Cdc2, Cdc3, CdcA3, Cdc4, CdcA4, Cdc5, Cdc6, Cdc7, Cdc10, Cdc11, Cdc13, Cdc14, Cdc14 Phosphatase, Cdc15, Cdc16, Cdc20, Cdc23, Cdc24, Cdc25, Cdc26, Cdc27, Cdc28, Cdc34, Cdc35, Cdc37, Cdc40, Cdc42, Cdc45, Cdc50, Cdc50C, Cdc53, Cdc123, Cdc42EP2, Cdc42EP4 and Cdc42EP5.

Also see Cdc Inhibitors or Cdc Substrates for functional analysis of cellular responses to Cdc.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Cdc6 Antibody (Ser 106) sc-12922 200 µg/ml $279
p-Cdc6 (Ser 106) P sc-12922 P
(peptide)
 100 µg/0.5 ml $61
p-Cdc6 Antibody (Ser 106)-R sc-12922-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Cdc6 siRNA (h) sc-29258 10 µM $258
Cdc6 (h)-PR sc-29258-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Cdc6 shRNA Plasmid (h) sc-29258-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Cdc6 shRNA (h) Lentiviral Particles sc-29258-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDC6 990 17q21.2 NM_001254 Q99741
 602627
 

Cdc6 is essential for DNA replication. Phosphorylation of Cdc6 is regulated during the cell cycle. In vitro, Cdc6 is an excellent substrate for Cdk2, while in vivo, Cdc6 is phosphorylated at three sites (Serine 54, Serine 74 and Serine 106). Serine 54, Serine 74 and Serine 106 are also phosphorylated by Cdk2 in vitro, which strongly suggests that Cdc6 is an endogenous Cdk substrate. Phosphorylation of Cdc6 by Cdks regulates DNA replication by promoting initiation of DNA replication and, subsequently, by preventing DNA rereplication through nuclear exclusion. Cdc6 is nuclear in G1, but translocates to the cytoplasm at the start of S phase via CRM1-dependent export. CRM1 binds to its cargo in the nucleus in the presence of a small nuclear GTPase protein, RanGTP. After the RanGTP-CRM1-cargo complex is translocated from the nucleus to the cytoplasm, RanGTP is hydrolyzed to RanGDP, causing the cargo to dissociate from CRM1.

p-Cdc6 Antibody (Ser 106) Product Citations
See how others have used p-Cdc6 Antibody (Ser 106) and or p-Cdc6 Antibody (Ser 106) conjugates.


1 total citations
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p-Cdc6 Antibody (Ser 106) Data
Click on image to enlarge
sc-12922
p-Cdc6 (Ser 106)-R: sc-12922-R. Western blot analysis of Cdc6 phosphorylation in serum starved then serum treated (A) and serum starved then serum and lambda protein phosphatase treated (B) HeLa whole cell lysates.
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