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p-p21 Antibody (Ser 146): sc-12902

 |  Datasheet

(Based on data analysis)
  • p-p21 Antibody (Ser 146) is a goat polyclonal IgG; also available as rabbit polyclonal provided at (sc-12902-R) provided at 200 µg/ml
  • epitope corresponding to phosphorylated Ser 146 of p21 of human origin
  • recommended for detection of Ser 146 phosphorylated p21 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-12902 P
  • See 4 citations for p-p21 Antibody (Ser 146)
 

See additional p21 Antibodies.

Also see p21 Activators for functional analysis of cellular responses to p21.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-p21 Antibody (Ser 146) sc-12902 200 µg/ml $279
p-p21 (Ser 146) sc-12902 P
(peptide)
 100 µg/0.5 ml $61
p-p21 Antibody (Ser 146) sc-12902-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p21 siRNA (h) sc-29427 10 µM $258
p21 siRNA (m) sc-29428 10 µM $258
p21 (h)-PR sc-29427-PR 10 µM, 20 µl $23
p21 (m)-PR sc-29428-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p21 shRNA Plasmid (h) sc-29427-SH 20 µg $520
p21 shRNA Plasmid (m) sc-29428-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p21 shRNA (h) Lentiviral Particles sc-29427-V 200 µl $625
p21 shRNA (m) Lentiviral Particles sc-29428-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDKN1A 1026 6p21.31 NM_000389, NM_078467 P38936
 116899
Mouse Cdkn1a 12575 17 A3.3 P39689
 N/A
 

The p53-inducible gene product, p21(WAF1/CIP1), plays a critical role in regulating the rate of tumor incidence (1). p21 is a kinase inhibitor that was originally identified as a cyclin-dependent kinase and PCNA-binding protein able to inhibit CDK catalytic activity and as a gene whose expression was induced by the tumor suppressor protein p53 (2–4,5). p21 contributes to the regulation of cell division, mediation of negative growth signals, differentiation and senescence, modulation of the apoptotic response and activaion of certain cyclin-CDKs in response to mitogenic signals (4,6,7). Serine 146 is a phosphorylation site within the carboxy terminal regulatory domain of p21 and when modified in vivo influences p21-PCNA interactions (1,5).

p-p21 Antibody (Ser 146) Product Citations
See how others have used p-p21 Antibody (Ser 146) and or p-p21 Antibody (Ser 146) conjugates.


4 total citations
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p-p21 Antibody (Ser 146) Data
Click on image to enlarge
sc-12902
p-p21 (Ser 146)-R: sc-12902-R. Western blot analysis of mouse recombinant p21 fusion protein incubated without (A) and with (B) human recombinant PKC.
sc-12902
Western blot analysis of p21 phosphorylation in untreated (A,D), human recombinant PKC α treated (B,E) and human recombinant PKC α and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant p21 fusion proteins. Antibodies tested include p-p21 (Ser 146)-R: sc-12902-R (A,B,C) and p21 (C-19): sc-397 (D,E,F).
sc-12902
p-p21 (Ser 146)-R: sc-12902-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing cytoplasmic and nuclear staining of epidermal cells.
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