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p-BRCA1 Antibody (Ser 988): sc-12888

 |  Datasheet

(Based on data analysis)
  • p-BRCA1 Antibody (Ser 988) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-12888-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Ser 988 of BRCA1 of human origin
  • recommended for detection of Ser 988 phosphorylated BRCA1 of human origin by WB, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine and porcine
  • blocking peptide, sc-12888 P
  • See 5 citations for p-BRCA1 Antibody (Ser 988)
 

See additional BRCA Antibodies including BRCA, BRAT1, BRCA1 and BRCA2.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-BRCA1 Antibody (Ser 988) sc-12888 200 µg/ml $279
p-BRCA1 (Ser 988) P sc-12888 P
(peptide)
 100 µg/0.5 ml $61
p-BRCA1 Antibody (Ser 988)-R sc-12888-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
BRCA1 siRNA (h) sc-29219 10 µM $258
BRCA1 (h)-PR sc-29219-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
BRCA1 shRNA Plasmid (h) sc-29219-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
BRCA1 shRNA (h) Lentiviral Particles sc-29219-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
HeLa + UV Cell Lysate sc-2221 500 µg/200 µl $104
K-562 + UV Cell Lysate sc-24724 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human BRCA1 672 17q21.31 NM_007294, NM_007295, NM_007296, NM_007297, NM_007298, NM_007299, NM_007300, NM_007302, NM_007303, NM_007304, NM_007305 P38398
 113705
 

BRCA1 is a cell cycle-regulated nuclear protein that is phosphorylated mainly on serine and to a lesser extent on threonine residues (1). Changes in phosphorylation occur in response to cell cycle progression and DNA damage (1). BRCA1 undergoes hyperphosphorylation during late G1 and S phases of the cell cycle (1). BRCA1 is a substrate of ATM kinase, and phosphorylation of BRCA1 requires the presence of a functional ATM protein (2,3). Chk2 regulates BRCA1 function after DNA damage by phosphorylating Serine 988 of BRCA1 (4). This phosphorylation is required for the release of BRCA1 from Chk2 and the ability of BRCA1 to restore survival after DNA damage (4). BRCA1 is also phosphorylated at Serine 1497, which is part of a cyclin-dependent kinase consensus site (1).

p-BRCA1 Antibody (Ser 988) Product Citations
See how others have used p-BRCA1 Antibody (Ser 988) and or p-BRCA1 Antibody (Ser 988) conjugates.


5 total citations
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p-BRCA1 Antibody (Ser 988) Data
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sc-12888
p-BRCA1 Antibody (Ser 988): sc-12888-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing nuclear and cytoplasmic staining of epidermal cells.
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