p-CaMKIIα (Thr 286)-R Antibody sc-12886-R

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p-CaMKIIα (Thr 286)-R Antibody: sc-12886-R	\| Datasheet

rabbit polyclonal IgG, 200 µg/ml
recommended for detection of CaMKIIα of mouse, rat and human origin phosphorylated at Thr 286 by WB, IP, IF, IHC(P) and ELISA
blocking peptide, sc-12886 P; also reactive with additional species, including equine, canine, bovine, porcine and avian
epitope corresponding to a short amino acid sequence containing phosphorylated Thr-286 of Ca⁺⁺/calmodulin-dependent protein kinase IIα (CaMKIIα) of human origin

Additional CaMK Antibodies ...

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WB IP IF IHC(P)

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	CAMK2A	815	5q33.1	NM_015981, NM_171825	Q9UQM7	114078
Mouse	Camk2a	12322	18 E1		P11798	N/A

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Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
p-CaMKIIα (Thr 286) P	sc-12886 P (peptide)	100 µg/0.5 ml	$61
p-CaMKIIα (Thr 286)-R	sc-12886-R	200 µg/ml	$279

WB Positive Control Cell Lysate (click product name for more information)

Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
mouse brain extract	sc-2253	500 µg/200 µl	$104

CaMKIIα Background Information
The Ca++/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV (1–4). CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca++ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription (1,2). There are four CaMKII isozymes designated å, ∫, © and ∂ which may or may not be co-expressed in the same tissue type (3,4). CaMKIIå is autophosphorylated on Thr-286 upon the binding of the Ca++/CaM complex to the autoinhibitory domain of CaMKII (5,6). This process is called Ca++/CaM trapping, which is thought to be involved in the synaptic encoding of information (5).

p-CaMKIIα (Thr 286)-R Product Citations

See how others have used p-CaMKIIα (Thr 286)-R: sc-12886-R antibody and or p-CaMKIIα (Thr 286)-R antibody conjugates.

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p-CaMKIIα (Thr 286)-R

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p-CaMKIIα (Thr 286): sc-12886. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining.

Western blot detection of CaMKII phosphorylation in mouse brain extracts. Blots were probed with CaMKII (M-176)-R: sc-9035-R (A) and p-CaMKIIα (Thr 286)-R: sc-12886-R (B,C). In B and C, the antibody was preincubated with cognate non-phosphorylated or phosphorylated peptide, respectively.

p-CaMKIIα (Thr 286)-R: sc-12886-R. Western blot analysis of CaMKIIα phosphorylation in non-transfected: sc-117752 (A) and mouse CaMKIIα transfected: sc-118982 (B) 293T whole cell lysates.

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p-CaMKIIα (Thr 286)-R Antibody: sc-12886-R