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p-Rsk (Ser 376) Antibody: sc-12883 |
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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-12883-R
- recommended for detection of Ser 376 phosphorylated Rsk-3 and correspondingly phosphorylated Rsk-1 and Rsk-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- blocking peptide, sc-12883 P; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Rsk Background Information
The family of ribosomal S6 kinases (Rsks), designated Rsk-1 (or MAPKAP kinase-1), Rsk-2 and Rsk-3, are intracellular serine/threonine kinases that are important signaling intermediates in response to a broad range of ligand activated receptor tyrosine kinases. A unique feature common to the members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. An additional Rsk protein, Rsk-4, shows a high level of homology to the three previously isolated members of the human Rsk family. Rsk-4 is most abundantly expressed in brain and kidney and plays a role in normal neuronal development. The family of ribosomal S6 kinases includes p70 S6 kinase and p70 S6 kinase b, which are thought to have similar regulatory functions. MSK1 (also designated RLPK) is a novel Rsk-related protein, which, like the p90 Rsk family members, contains two non-identical complete kinase catalytic domains. |
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p-Rsk (Ser 376)
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Western blot analysis of λphosphatase-treated (A,C,E) and untreated (B,D,F) active human recombinant Rsk. Antibodies tested include Rsk-1 (C-21): sc-231 (A,B), p-Rsk (Ser 376): sc-12883 (C,D) and p-Rsk (Ser 376)-R: sc-12883-R (E,F). |
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