epitope mapping at the N-terminus of CLIP-170 of human origin
recommended for detection of CLIP-170 and restin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
CLIP-170 Background Information Cytoplasmic linker protein (CLIP-170) is the original member of a group of microtuble binding proteins designated as plus-end-binding proteins (+TIPs). CLIP-170 binds to the growing plus ends of microtubules and acts as a linker between the dynamic microtubule ends and organelle membranes. The protein acts as an anticatastrophic factor, promoting microtubule rescue near the cell periphery. Fluorescently labeled CLIP-170 can be visualized as a comet like streak around the growing ends of microtubules. CLIP-170 co-localizes with Dynactin and Dynein at microtubule ends and also at the kinetochore. Restin, first identified as a marker for Hodgkin and Reed-Sternberg (HRS) cells, is a splice variant of the gene that includes a 35 amino acid stretch not present in CLIP-170. CLIP-170/restin is highly expressed in HRS cells, monocyte-derived dendritic cells, IL-4 + CD40L activated B cells and Ki-1 lymphoma.
CLIP-170 (N-18) Product Citations
See how others have used CLIP-170 (N-18): sc-12799 antibody and or CLIP-170 (N-18) antibody conjugates.
1 total citations
Loading citations.
CLIP-170 (N-18)
Click on image to enlarge
CLIP-170 (N-18): sc-12799. Western blot analysis of CLIP-170 expression in KNRK (A), HeLa (B) and Hep G2 (C) whole cell lysates.
CLIP-170 (N-18): sc-12799. Western blot analysis of CLIP-170 expression in non-transfected: sc-117752 (A) and mouse CLIP-170 transfected: sc-119308 (B) 293T whole cell lysates.
