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IL-1α (ALF-161) Antibody: sc-12741 |
| Datasheet |
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- Armenian hamster monoclonal IgG, 200 µg/ml
- raised against full length purified recombinant IL-1α of mouse origin
- recommended for detection of IL-1α of mouse and human origin by WB, IP, IF, FCM and ELISA
- fluorescein conjugate for FCM analysis, sc-12741 FITC, 200 µg/ml
- also provided azide-free for neutralization, sc-12741 L, 200 µg/0.1 ml
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
IL1A |
3552 |
2q13 |
NM_000575 |
P01583
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147760 |
| Mouse |
Il1a |
16175 |
2 F1 |
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P01582
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N/A |
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IL-1α Background Information
ALF (TFIIA a/b like factor), also known as GTF2A1L (general transcription factor IIA 1-like), is a nuclear and cytoplasmic protein that is specifically expressed in haploid spermatids in the testis. ALF is believed to play a role in spermatogenesis, functioning as a transcription factor, and is related to the large a/b subunit of TFIIA, existing as the germ cell-specific paralog. Similar to TFIIA-?/?, ALF associates with the smaller TFIIA subunit, TFIIA-?, and functions to stabilize the interaction between TBP and DNA by binding directly to TBP and the DNA (at the TATA box), thus forming a TBP/ALF/TATA complex which mediates the transcriptional output of a gene. Low expression levels of ALF have been associated with abnormal spermatogenesis and male infertility, further implying a role for ALF in spermatogenic cell function. The transcriptional expression of ALF appears to be regulated by DNA methylation. |
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IL-1α (ALF-161)
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IL-1α (ALF-161): sc-12741. Western blot analysis of mouse recombinant IL-1α.
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