Syntaxin 1 (HPC-1) Antibody: sc-12736

Syntaxin 1 Background Information
Correct vesicular transport is essential to the survival of eukaryotic cells. This process is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). This complex then recruits soluble NSF attachment proteins (SNAPs) and N-ethylmaleimide-sensitive factor (NSF) to form the highly stable SNAP receptor (SNARE) complex. The formation of a SNARE complex pulls the vesicle and target membrane together and may provide the energy to drive fusion of the lipid bilayers. SNAPs, including a- and g-SNAP, are cytoplasmic proteins that bind to a membrane receptor complex composed of VAMP, SNAP 25 and Syntaxin 1. Syntaxins, including Syntaxin 1, comprise a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane. The Syntaxin family displays broad tissue distribution and contains C-terminal hydrophobic domains that direct them to their respective intracellular compartments.