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p-PP2A-Cα/β Antibody (Tyr 307): sc-12615

 |  Datasheet

(Based on data analysis)

  • p-PP2A-Cα/β Antibody (Tyr 307) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-12615-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Tyr 307 of PP2A-Cα of mouse origin
  • recommended for detection ofTyr 307 phosphorylated PP2A-C α and β isoforms broadly reactive with multiple species by WB, IP, IF and ELISA
  • blocking peptide, sc-12615 P
  • See 10 citations for p-PP2A-Cα/β Antibody (Tyr 307)
 

See additional PP2 Antibodies including PP2, PP2A-B55-β , PP2A-B55-δ, PP2A-Cβ, PP2Comega, PP2A-A alpha, PP2A-A alpha / beta, PP2A-C , PP2A-C alpha, PP2A-C alpha / beta, PP2B-A, PP2B-A alpha, PP2B-A beta, PP2B-A gamma, PP2C alpha, PP2C alpha / beta, PP2C beta, PP2C epsilon, PP2C eta, PP2C gamma, PP2C kappa, PP2C zeta, PP2B-B1, PP2B-B2, PP2A-B55, PP2A-B55-alpha, PP2A-B55-gamma, PP2A-B56-alpha, PP2A-B56-beta, PP2A-B56-delta, PP2A-B56-gamma, PP2A-B72 and PP2A-B130.

Also see PP2 Inhibitors, PP2 Activators or PP2 Substrates for functional analysis of cellular responses to PP2.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-PP2A-Cα/β Antibody (Tyr 307) sc-12615 200 µg/ml $279
p-PP2A-Cα/β (Tyr 307) P sc-12615 P
(peptide)
 100 µg/0.5 ml $61
p-PP2A-Cα/β Antibody (Tyr 307)-R sc-12615-R 200 µg/ml $279

The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.

p-PP2A-Cα/β Antibody (Tyr 307) Product Citations
See how others have used p-PP2A-Cα/β Antibody (Tyr 307) and or p-PP2A-Cα/β Antibody (Tyr 307) conjugates.


10 total citations
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p-PP2A-Cα/β Antibody (Tyr 307) Data
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sc-12615
p-PP2A-Cα/β (Tyr 307): sc-12615. Western blot analysis of PP2A-Ca/b phosphorylation in MCF7 whole cell lysate.
sc-12615
Western blot analysis of PP2A-Cα/β phosphorylation in untreated (A,D), EGF treated (B,E) and EGF and Alkaline phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-PP2A-Cα/β (Tyr 307)-R: sc-12615-R (A,B,C) and PP2A-Cα/β (1D6): sc-80665 (D,E,F).
sc-12615
Western blot analysis of PP2A-C&alphla;/β phosphorylation in untreated (A,C) and EGF treated (B,D) HeLa whole cell lysates. Antibodies tested include p-PP2A-C&alphla;/β (Tyr 307)-R: sc-12615-R (A,B) and PP2A-C&alphla;/β (1D6): sc-80665 (C,D).
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