epitope mapping within an internal region of cyclin T2a/b of human origin
recommended for detection of cyclin T2a and cyclin T2b of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
cyclin T2a/b Background Information Cyclin T1 was identified as a partner for Cdk9, an RNA polymerase II (RNAPII) transcription elongation factor. Cyclin T1 interacts with the transactivation domain of the HIV-1 Tat protein. The interaction of Tat with cyclin T1 enhances the affinity of Tat for the viral TAR RNA stem-loop structure, suggesting that Tat can recruit cyclin T1/cdk9 to RNAPII through cooperative binding to TAR. The human positive transcription elongation factor b (P-TEFb) consists of a cyclin dependent kinase, cdk9, paired with a cyclin T. Cdk9 may be paired with either cyclin T1 or cyclin T2, in a mutually exclusive manner. Two forms of cyclin T2, T2a and T2b, are due to alternative splicing. The binding of Tat to TAR was shown to be facilitated by human cyclin T1, but not by cyclins T2a or T2b. Cyclin T2 binds to Cdk9 but not to Tat, and cyclin T2 can inhibit cyclin T1-mediated Tat activity.
cyclin T2a/b (A-20) Product Citations
See how others have used cyclin T2a/b (A-20): sc-12419 antibody and or cyclin T2a/b (A-20) antibody conjugates.
