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ZO-2 Antibody (C-16): sc-12386

 |  Datasheet

(Based on data analysis)

  • ZO-2 Antibody (C-16) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of ZO-2 of human origin
  • recommended for detection of ZO-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
  • blocking peptide, sc-12386 P

See additional ZO Antibodies including ZO-3, ZO-2, ZO-1 and ZO.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 Antibody (C-16) sc-12386 200 µg/ml $279
ZO-2 (C-16) P sc-12386 P
100 µg/0.5 ml $61
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 CRISPR/Cas9 KO Plasmid (h) sc-401395 20 µg $345
ZO-2 HDR Plasmid (h) sc-401395-HDR 20 µg $385
ZO-2 CRISPR/Cas9 KO Plasmid (m) sc-423408 20 µg $345
ZO-2 HDR Plasmid (m) sc-423408-HDR 20 µg $385
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 CRISPR Activation Plasmid (h) sc-401395-ACT 20 µg $345
ZO-2 CRISPR Activation Plasmid (m) sc-423408-ACT 20 µg $345
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 siRNA (h) sc-29833 10 µM $258
ZO-2 siRNA (m) sc-29926 10 µM $258
ZO-2 (h)-PR sc-29833-PR 10 µM, 20 µl $23
ZO-2 (m)-PR sc-29926-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 shRNA Plasmid (h) sc-29833-SH 20 µg $520
ZO-2 shRNA Plasmid (m) sc-29926-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ZO-2 shRNA (h) Lentiviral Particles sc-29833-V 200 µl $625
ZO-2 shRNA (m) Lentiviral Particles sc-29926-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
rat cerebellum extract sc-2398 500 µg/200 µl $104
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TJP2 9414 9q21.11 NM_004817, NM_201629 Q9UDY2
Mouse Tjp2 21873 19 B Q9Z0U1

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane-associated guanylate kinase (MAGUK) family and include occludin, ZO-1, ZO-2 and ZO-3 (1,2). These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain (3). ZO-1 forms complexes with either ZO-2 or ZO-3 (4). In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction (5-7). ZO-1 expression is significantly reduced in many breast cancer lines (8). ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue (2,3).

ZO-2 Antibody (C-16) Data
Click on image to enlarge
ZO-2 (C-16): sc-12386. Western blot analysis of ZO-2 expression in HeLa whole cell lysate.