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MT-MMP-1 (V-16) Antibody: sc-12366 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of MT-MMP-1 of human origin
- recommended for detection of MT-MMP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-12366 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MMP14 |
4323 |
14q11.2 |
NM_004995 |
P50281
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600754 |
| Mouse |
Mmp14 |
17387 |
14 C2 |
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P53690
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N/A |
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MT-MMP-1 Background Information
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan (1). Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) (2). MMP catalysis requires both calcium and zinc (3). Membrane-type matrix metalloproteinases, including MT-MMP-1 (also designated MMP-14), MT-MMP-2 (also designated MMP-15), MT-MMP-3 (also designated MMP-16) and MT-MMP-4 (also designated MMP-17) are type I membrane proteins that function to activate other MMPs (4,5). MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover (6,7).
| MT-MMP-1 (V-16) Product Citations |
See how others have used MT-MMP-1 (V-16): sc-12366 antibody and or MT-MMP-1 (V-16) antibody conjugates.
5 total citations Loading citations.
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MT-MMP-1 (V-16)
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MT-MMP-1 (V-16): sc-12366. Western blot analysis of MT-MMP-1 expression in MIA PaCa-2 whole cell lysate.
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