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home » Cell Cycle Proteins » Cdc Antibody / Cdc Antibodies » p-Cdc2 p34 (Thr 161): sc-12341

p-Cdc2 p34 (Thr 161) Antibody: sc-12341

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-12341-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Thr 161 of Cdc2 p34 of human origin
  • recommended for detection of Thr 161 phosphorylated Cdc2 p34 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-12341 P
 
Additional Cdc Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDC2 983 10q21.2 NM_001786, NM_033379 P06493
 116940
Mouse Cdc2a 12534 10 B5.3 P11440
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-Cdc2 p34 (Thr 161) sc-12341 200 µg/ml $279
p-Cdc2 p34 (Thr 161) P sc-12341 P
(peptide)
 100 µg/0.5 ml $61
p-Cdc2 p34 (Thr 161)-R sc-12341-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Saos-2 + hydroxyurea Cell Lysate sc-2286 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
HeLa + hydroxyurea Cell Lysate sc-24682 500 µg/200 µl $104
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104

Cdc2 p34 Background Information
Cdc2, an evolutionarily conserved serine/threonine-specific protein kinase, is essential in the cell cycle transition from G2 to M phase. Cdc2 is regulated by association with B-type cyclins and by reversible phosophorylation. Cyclin B binding facilitates the phosphorylation of Cdc2 p34 on three regulatory sites: threonine 14, tyrosine 15, and threonine 161. In higher eukaryotes, Cdc2 is negatively regulated by phosphorylation of two residues located in the ATP-binding site, Thr 14 and Tyr 15. Cdc2 is positively regulated by the cyclin-dependent phosphorylation of Thr 161. Both phosphorylation and de- phosphorylation at Thr 161 are required for progression through the cell cycle.

p-Cdc2 p34 (Thr 161) Product Citations
See how others have used p-Cdc2 p34 (Thr 161): sc-12341 antibody and or p-Cdc2 p34 (Thr 161) antibody conjugates.


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p-Cdc2 p34 (Thr 161)
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sc-12341
p-Cdc2 p34 (Thr 161)-R: sc-12341-R. Western blot analysis of Cdc2 p34 phosphorylation in HeLa whole cell lysate.
sc-12341
Western blot analysis of Cdc2 p34 phosphorylation in untreated (A,D), nocodazole treated (B,E) and nocodazole and lambda protein phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-Cdc2 p34 (Thr 161)-R: sc-12341-R (A,B,C) and p-Cdc2 p34 (PSTAIRE): sc-53 (D,E,F).
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