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home » Transcription Regulators » CGBP Antibody / CGBP Antibodies » CGBP (C-20): sc-12339

CGBP (C-20) Antibody: sc-12339

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of CGBP of human origin
  • recommended for detection of CGBP of mouse, rat and human origin by WB, IF, indirect FCM using FITC-conjugated donkey anti-goat IgG: sc-2024 and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-12339 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-12339 X, 200 µg/0.1 ml
 
Additional CGBP Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   FCM   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CXXC1 30827 18q21.1 NM_014593 Q9P0U4
 609150
Mouse Cxxc1 74322 18 E2 Q9CWW7
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CGBP (C-20) sc-12339 200 µg/ml $279
CGBP (C-20) P sc-12339 P
(peptide)
 100 µg/0.5 ml $61
CGBP (C-20) X sc-12339 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CGBP siRNA (h) sc-35055 10 µM $258
CGBP siRNA (m) sc-35056 10 µM $258
CGBP (h)-PR sc-35055-PR 10 µM $23
CGBP (m)-PR sc-35056-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CGBP shRNA Plasmid (h) sc-35055-SH 20 µg $520
CGBP shRNA Plasmid (m) sc-35056-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CGBP shRNA (h) Lentiviral Particles sc-35055-V 200 µl $625
CGBP shRNA (m) Lentiviral Particles sc-35056-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat nuclear extract sc-2132 1000 µg $143
K-562 nuclear extract sc-2130 1000 µg $143
NIH/3T3 nuclear extract sc-2138 1000 µg $143
CGBP (m): 293T Lysate sc-119204 100µg/200µl $205
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104

CGBP Background Information
The human genome contains discrete clusters of unmethylated CpG dinucleotides, called CpG islands, which contribute to the modulation of gene expression by binding transcription factors (1-4). Human CpG binding protein (CGBP), detected in K562 cells, is a widely expressed member of CpG binding proteins that requires the CpG dinucleotide to bind DNA (1). CGBP binds specifically to unmethylated CpG motifs and functions as a transcriptional activator (1). The CXXC domain of CGBP is conserved in DNA methyltransferase, human trithorax, and methyl-CpG binding protein (MBP), and is involved in DNA-binding (1,5,6). CGBP also contains several domains implicated in protein-protein interactions, such as a coiled-coil domain, and two PHD finger domains, the function of which remains to be determined (1).
CGBP (C-20)
Click on image to enlarge
sc-12339
CGBP (C-20): sc-12339. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear staining.
sc-12339
CGBP (C-20): sc-12339. Indirect, intracellular FCM analysis of fixed and permeabilized K-562 cells stained with CGBP (C-20) followed by FITC-conjugated donkey anti-goat IgG: sc-2024. Black line histogram represents the isotype control, normal goat IgG: sc-3887.
sc-12339
Western blot analysis of CGBP expression in Jurkat (A,C) and K-562 (B,D) nuclear extracts. Antibodies tested include CGBP (N-21): sc-12336 (A,B) and CGBP (C-20): sc-12339 (C,D).
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