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home » Signaling Intermediates » c-Cbl Associated Protein Antibody / c-Cbl Associated Protein Antibodies » CAP (M-20): sc-12299

CAP (M-20) Antibody: sc-12299

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the C-terminus of CAP of mouse origin
  • recommended for detection of CAP of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and porcine
  • blocking peptide, sc-12299 P
 
Additional c-Cbl Associated Protein Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Sorbs1 20411 19 C3 Q62417
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CAP (M-20) sc-12299 200 µg/ml $279
CAP (M-20) P sc-12299 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAP siRNA (m) sc-40340 10 µM $258
CAP (m)-PR sc-40340-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAP shRNA Plasmid (m) sc-40340-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAP shRNA (m) Lentiviral Particles sc-40340-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
3T3-L1 Cell Lysate sc-2243 500 µg/200 µl $104
CAP (m): 293T Lysate sc-118986 100µg/200µl $205

CAP Background Information
c-Cbl associated protein (CAP), also designated ponsin and SH3P12, interacts with c-Cbl and facilitates the tyrosine phosphorylation of c-Cbl in response to insulin. CAP contains three adjacent Src homology-3 (SH3) domains in the carboxy terminus. It interacts with the focal adhesion kinase p125FAK and co-localizes with Actin stress fibers. CAP is expressed in 3T3-L1 adipocytes, but not in 3T3-L1 or NIH/3T3 fibroblasts. Expression of the CAP gene is stimulated by thiazolidinediones (TZDs) through activation of PPARg. In addition to its interaction with c-Cbl, CAP interacts with Sos through the same SH3 domain, and may facilitate protein-protein associations involved in cell structural changes.
CAP (M-20)
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sc-12299
CAP (M-20): sc-12299. Western blot analysis of CAP expression in non-transfected: sc-117752 (A) and mouse CAP transfected: sc-118986 (B) 293T whole cell lysates.
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