MDC (M-15) Antibody: sc-12288

MDC Background Information
Chemokines have been implicated in the regulation of stem/progenitor cell proliferation and movement. The C-C chemokines TARC (for thymus and activation-regulated chemokine, also designated small inducible cytokine A17) and MDC (for macrophage-derived chemokine, also designated small inducible cytokine A22 or STCP-1, for stimulated T cell chemotactic protein 1), are expressed in the thymus and spleen. C-C chemokine receptor CCR4, expressed by T helper type 2 polarized cells, is a high affinity receptor for both TARC and MDC. TARC is important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to its target tissues. MDC is involved in chronic inflammation and dendritic cell and lymphocyte homing. MDC and TARC lack suppressive activity against immature subsets of myeloid progenitors, which have been stimulated to proliferate by multiple growth factors .