epitope mapping near the N-terminus of DAP-1 of human origin
recommended for detection of DAP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
DAP-1 Background Information In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved cytoplasmic region called the “death domain”. DAP-1 (for death associated protein-1) is a basic, proline-rich protein expressed in gamma interferon (IFN-gamma)-induced HeLa cells. DAP-1 is a member of the ubiquitin homology (UbH) family which also includes SUMO-1 and SIII p18 elogin protein. DAP-1 interacts with the death domain of TNF-R1 and can trigger programmed cell death in a variety of cell lines, as well as suppress NF-kB/Rel activity.
DAP-1 (A-16)
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DAP-1 (A-16): sc-12191. Western blot analysis of DAP-1 expression in non-transfected: sc-117752 (A) and mouse DAP-1 transfected: sc-119658 (B) 293T whole cell lysates.
