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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of NAB2 of human origin
- recommended for detection of NAB2 of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-12151 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
NAB2 |
4665 |
12q13.3 |
NM_005967 |
Q15742
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n/a |
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NAB2 Background Information
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2 are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas, and liposarcomas. |
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NAB2 (A-15)
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NAB2 (A-15): sc-12151. Western blot analysis of NAB2 expression in non-transfected: sc-117752 (A) and human NAB2 transfected: sc-117107 (B) 293T whole cell lysates. |
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