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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of OCRL of human origin
- recommended for detection of OCRL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- blocking peptide, sc-12087 P
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Ordering Information
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OCRL Background Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder that is characterized in part by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction. OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate, and inositol 1,3,4,5-tetrakisphosphate as substrates. OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), which suggests that OCRL1 plays a role in protein sorting and trafficking within the cell. |
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OCRL (N-16)
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OCRL (N-16): sc-12087. Western blot analysis of OCRL expression in KNRK whole cell lysate.
OCRL (N-16): sc-12087. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining (A). Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic staining (B).
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