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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of OGG1/2 of human origin
- recommended for detection of all OGG1 splice variants of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-12075 P
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OGG1/2 Background Information
8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes 8 isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria.
| OGG1/2 (L-19) Product Citations |
See how others have used OGG1/2 (L-19): sc-12075 antibody and or OGG1/2 (L-19) antibody conjugates.
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OGG1/2 (L-19)
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OGG1/2 (L-19): sc-12075. Western blot analysis of OGG1/2 expression in HeLa (A) and Jurkat (B) whole cell lysates.
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