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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of OGG1/2 of human origin
- recommended for detection of OGG1 splice variants of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-12074 P
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Ordering Information
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OGG1/2 Background Information
8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes 8 isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. |
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OGG1/2 (N-20)
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OGG1/2 (N-20): sc-12074. Western blot analysis of OGG1/2 expression in non-transfected 293T: sc-117752 (A), human OGG1/2 transfected 293T: sc-174305 (B) and HeLa (C) whole cell lysates. |
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