epitope mapping at the N-terminus of Dhh of mouse origin
recommended for detection of the N-terminal subunit of Dhh of mouse, rat, human and Xenopus origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine and bovine
Dhh Background Information The Drosophila segment polarity gene hedgehog (hh) encodes a precursor protein which undergoes autocleavage to generate amino and carboxy terminal peptides. Both proteins are secreted and appear to function in embryonic and imaginal disc patterning. Several vertebrate homologs of Drosophila hh have been identified. These include Sonic hedgehog (Shh) (alternatively designated Vhh-1), Desert hedgehog (Dhh) and Indian hedgehog (Ihh). Each contain amino terminal signal peptides and apparently function as secreted proteins involved in the mediation of various cell-cell interactions. Shh resembles Drosophila hh in that it is processed to generate an amino terminal secreted peptide that is retained at or near the cell surface and a carboxy terminal glycosylated more diffusible peptide.
Dhh (N-19) Product Citations
See how others have used Dhh (N-19): sc-1193 antibody and or Dhh (N-19) antibody conjugates.
Dhh (N-19): sc-1193. Western blot analysis of Dhh expression in non-transfected: sc-117752 (A) and human Dhh transfected: sc-114457 (B) 293T whole cell lysates.
Dhh (N-19): sc-1193. Western blot analysis of Dhh expression in mouse embryo tissue extract.
Dhh (N-19): sc-1193. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of islet of langerhans cells.
