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NFκB p50 (C-19) Antibody: sc-1190 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of NFκB p50 of human origin
- recommended for detection of NFκB p50 and p105 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-1190 P
- agarose conjugate for IP studies, sc-1190 AC, 500 µg/0.25 ml agarose
- TransCruz reagent for Gel Supershift and ChIP applications, sc-1190 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
NFKB1 |
4790 |
4q24 |
NM_003998 |
P19838
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164011 |
| Mouse |
Nfkb1 |
18033 |
3 G3 |
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P25799
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N/A |
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NFκB p50 Background Information
Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF˚B (p50 and p65) and the Drosophila maternal morphagen, dorsal. These proteins share sequence homology over a region of 300 amino acids at their NH2-terminus, the region that contains their DNA binding and dimerization domains. The DNA binding activity of NF˚B is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described. These proteins, designated p105 and p100, are highly related but map on different chromosomes. The p105 (p110) precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated PdI, binds to p50 and regulates its activity.
| NFκB p50 (C-19) Product Citations |
See how others have used NFκB p50 (C-19): sc-1190 antibody and or NFκB p50 (C-19) antibody conjugates.
94 total citations Loading citations.
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NFκB p50 (C-19)
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NFκB p50 (C-19): sc-1190. Western blot analysis of NFκB p50 and its precursor, p105, in CTLL-2 whole cell lysate.
ChIP analysis of cofactor occupancy dynamics on the KAI1 promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, HDAC3 (H-99): sc-11417, HDAC3 (N-19): sc-8138, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek et al., Cell 2002, 110: 55-67.
ChIP analysis of cofactor occupancy dynamics on the ICAM1 promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038, PCAF (C-16): sc-6300, PCAF (H-369): sc-8999, CBP (A-22): sc-369, CBP (C-1): sc-7300, CBP (C-20): sc-583, CBP (451): sc-1211. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek et al., Cell 2002, 110: 55-67.
ChIP analysis of cofactor occupancy dynamics on the IL-8 promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, CBP (A-22): sc-369, CBP (C-1): sc-7300, CBP (C-20): sc-583, CBP (451): sc-1211, p300 (C-20): sc- sc-585, p300 (N-15): sc-584, p300 (H-272): sc-8981. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek et al., Cell 2002, 110: 55-67. NFκB p50 (C-19): sc-1190. Western blot analysis of NFκB p50 expression in non-transfected: sc-117752 (A) and human NFκB p50 transfected: sc-116112 (B) 293T whole cell lysates. NFκB p50 (C-19): sc-1190. Western blot analysis of NFκB p50 expression in non-transfected: sc-117752 (A) and mouse NFκB p50 transfected: sc-122025 (B) 293T whole cell lysates. NFkB p50 (C-19): sc-1190. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of respiratory epithelial cells, smooth muscle cells & macrophages.
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