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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of Lsh of mouse origin
- recommended for detection of Lsh of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-11841 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-11841 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HELLS |
3070 |
10q23.33 |
NM_018063 |
Q9NRZ9
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603946 |
| Mouse |
Hells |
15201 |
19 C3 |
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Q60848
|
N/A |
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Lsh Background Information
The SNF2 family of helicases are thought to act as transcriptional regulators by their ability to alter the structure of chromatin. One such member, Lymphoid-Specific Helicase (Lsh, also designated Hells for lymphoid-specific DNA helicase), is highly expressed in lymphoid precursor cells in adult animals and is required for the proliferation of peripheral T lymphocytes. Lsh is also expressed in fetal liver and more abundantly in fetal thymus. Lsh protein shows substantial homology to other members of the SNF2 family that are involved in chromatin remodeling and transcription, however does not show similarity to members involved in DNA repair or recombination. The similarity of Lsh to another SNF2 homolog, Mi-2, which functions as a transcriptional silencer in chromatin remodeling, suggests that Lsh may participate in chromatin repression to regulate transcription, rather than chromatin “opening”.
| Lsh (N-16) Product Citations |
See how others have used Lsh (N-16): sc-11841 antibody and or Lsh (N-16) antibody conjugates.
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Lsh (N-16)
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Lsh (N-16): sc-11841. Western blot analysis of Lsh expression in CCRF-CEM nuclear extract.
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