Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Kinases and Phosphatases » p70 Antibodies » p-p70 S6 kinase α Antibody (Thr 389): sc-11759

p-p70 S6 kinase α Antibody (Thr 389): sc-11759

 |  Datasheet

(Based on data analysis)

  • p-p70 S6 kinase α Antibody (Thr 389) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-11759-R
  • epitope corresponding to a short amino acid sequence containing phosphorylated Thr 389 of p-p70 S6 kinase α of human origin
  • recommended for detection of Thr 389 phosphorylated p70 S6 kinase of mouse, rat and human orign by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-11759 P
  • See 26 citations for p-p70 S6 kinase α Antibody (Thr 389)
 

See additional p70 Antibodies.

Also see p70 S6 Kinase Inhibitors or p70 Inhibitors for functional analysis of cellular responses to p70.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-p70 S6 kinase α Antibody (Thr 389) sc-11759 200 µg/ml $279
p-p70 S6 kinase α (Thr 389) P sc-11759 P
(peptide)
 100 µg/0.5 ml $61
p-p70 S6 kinase α Antibody (Thr 389)-R sc-11759-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p70 S6 kinase α siRNA (h) sc-36165 10 µM $258
p70 S6 kinase α siRNA (m) sc-36166 10 µM $258
p70 S6 kinase α siRNA (h2) sc-44318 10 µM $258
p70 S6 kinase α (h)-PR sc-36165-PR 10 µM, 20 µl $23
p70 S6 kinase α (m)-PR sc-36166-PR 10 µM, 20 µl $23
p70 S6 kinase α (h2)-PR sc-44318-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p70 S6 kinase α shRNA Plasmid (h) sc-36165-SH 20 µg $520
p70 S6 kinase α shRNA Plasmid (m) sc-36166-SH 20 µg $520
p70 S6 kinase α shRNA Plasmid (h2) sc-44318-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p70 S6 kinase α shRNA (h) Lentiviral Particles sc-36165-V 200 µl $625
p70 S6 kinase α shRNA (m) Lentiviral Particles sc-36166-V 200 µl $625
p70 S6 kinase α shRNA (h2) Lentiviral Particles sc-44318-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human RPS6KB1 6198 17q23.1 NM_003161 P23443
 608938
Mouse Rps6kb2 58988 19 A Q9Z1M4
 N/A
Mouse Rps6kb1 72508 11 C Q8BSK8
 N/A
 

In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine (Ser/Thr) kinases have been identified. Included among such kinases are two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine and tyrosine residues by a protein kinase designated MEK.

p-p70 S6 kinase α Antibody (Thr 389) Product Citations
See how others have used p-p70 S6 kinase α Antibody (Thr 389) and or p-p70 S6 kinase α Antibody (Thr 389) conjugates.


26 total citations
Loading citations.
 
p-p70 S6 kinase α Antibody (Thr 389) Data
Click on image to enlarge
sc-11759
p-p70 S6 kinase α (Thr 389)-R: sc-11759-R. Western blot analysis of p70 S6 kinase α phosphorylation in non-transfected 293T: sc-117752 (A), mouse p70 S6 kinase α transfected 293T: sc-125770 (B) and NIH/3T3 (C) whole cell lysates.
sc-11759
Western blot analysis of p70 S6 kinase α phosphorylation in untreated (A, C), and lambda protein phosphatase treated (B, D) NIH/3T3 whole cell lysates. Antibodies tested include p-p70 S6 kinase α (Thr 389)-R: sc-11759-R (A, B) and p70 S6 kinase α (H-160): sc-9027 (C, D).
Download
Datasheets
Get Adobe Acrobat Reader