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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of R1 of human origin
- recommended for detection of R1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-11733 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
RRM1 |
6240 |
11p15.4 |
NM_001033 |
P23921
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180410 |
| Mouse |
Rrm1 |
20133 |
7 E3 |
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P07742
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N/A |
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R1 Background Information
Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTP’s) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R1, the larger subunit, contains allosteric regulatory sites. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. Ribonucleotide reductase appears to be specifically involved in nucleotide excision repair, since both the R1 and R2 subunits are induced in response to UV light in a dose-dependent manner.
| R1 (T-16) Product Citations |
See how others have used R1 (T-16): sc-11733 antibody and or R1 (T-16) antibody conjugates.
6 total citations Loading citations.
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R1 (T-16)
Click on image to enlarge
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R1 (T-16): sc-11733. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic localization.
R1 (T-16): sc-11733. Western blot analysis of R1 expression in HeLa whole cell lysate.
R1 (T-16): sc-11733. Western blot analysis of R1 expression in Ramos whole cell lysate.
R1 (T-16): sc-11733. Western blot analysis of R1 expression in non-transfected 293T: sc-117752 (A), human R1 transfected 293T: sc-171995 (B) and A549 (C) whole cell lysates. R1 (T-16): sc-11733. Western blot analysis of R1 expression in non-transfected: sc-117752 (A) and human R1 transfected: sc-171262 (B) 293T whole cell lysates. R1 (T-16): sc-11733. Western blot analysis of R1 expression in non-transfected 293T: sc-117752 (A), human R1 transfected 293T: sc-158910 (B) and HeLa (C) whole cell lysates. |
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